Subthalamic nucleus stimulation modulates afferent inhibition in Parkinson disease
Identifieur interne : 002640 ( Main/Exploration ); précédent : 002639; suivant : 002641Subthalamic nucleus stimulation modulates afferent inhibition in Parkinson disease
Auteurs : A. Sailer [Canada, Suède] ; D. I. Cunic [Canada] ; G. O. Paradiso [Canada] ; C. A. Gunraj [Canada] ; A. Wagle-Shukla [Canada] ; E. Moro [Canada] ; A. M. Lozano [Canada] ; A. E. Lang [Canada] ; R. Chen [Canada]Source :
- Neurology [ 0028-3878 ] ; 2007.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
Background: Peripheral sensory stimulation at the wrist inhibits the motor cortex as measured by transcranial magnetic stimulation at interstimulus intervals of approximately 20 ms (short latency afferent inhibition [SAI]) and 200 ms (long latency afferent inhibition [LAI]). Previous studies suggested that reduced SAI in Parkinson disease (PD) reflects adverse effect of dopaminergic medications and reduced LAI may be related to nondopaminergic manifestations of PD. We hypothesize that subthalamic nucleus (STN) deep brain stimulation (DBS) may correct these deficiencies. Methods: We studied the effects of STN DBS on SAI and LAI in seven PD patients and age-matched controls. PD patients were studied in an off medication followed by an on medication session, with the stimulator switched on or off in random order in each session. Results: In the on medication session, SAI was reduced in the stimulator off condition and was restored by STN DBS. LAI was partially normalized by STN DBS in the medication on condition. Conclusions: Subthalamic nucleus (STN) stimulation improves short latency afferent inhibition, suggesting that it could normalize pathways that are adversely affected by dopaminergic medications. The effect of STN stimulation on long latency afferent inhibition suggests that it may influence nondopaminergic pathways involved in sensorimotor integration.
Affiliations:
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Sailer</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Neurology, Krembil Neuroscience Centre and Toronto Western Research Institute, University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Pharmacology and Clinical Neuroscience, Division of Clinical Neurophysiology, Umea University</s1><s3>SWE</s3><sZ>1 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Department of Pharmacology and Clinical Neuroscience, Division of Clinical Neurophysiology, Umea University</wicri:noRegion></affiliation></author><author><name sortKey="Cunic, D I" sort="Cunic, D I" uniqKey="Cunic D" first="D. 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Lozano</name><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Division of Neurosurgery, Krembil Neuroscience Centre and Toronto Western Research Institute, University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>7 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Lang, A E" sort="Lang, A E" uniqKey="Lang A" first="A. E." last="Lang">A. E. 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Sailer</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Neurology, Krembil Neuroscience Centre and Toronto Western Research Institute, University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Pharmacology and Clinical Neuroscience, Division of Clinical Neurophysiology, Umea University</s1><s3>SWE</s3><sZ>1 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Department of Pharmacology and Clinical Neuroscience, Division of Clinical Neurophysiology, Umea University</wicri:noRegion></affiliation></author><author><name sortKey="Cunic, D I" sort="Cunic, D I" uniqKey="Cunic D" first="D. I." last="Cunic">D. I. Cunic</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Neurology, Krembil Neuroscience Centre and Toronto Western Research Institute, University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Paradiso, G O" sort="Paradiso, G O" uniqKey="Paradiso G" first="G. O." last="Paradiso">G. O. Paradiso</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Neurology, Krembil Neuroscience Centre and Toronto Western Research Institute, University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Gunraj, C A" sort="Gunraj, C A" uniqKey="Gunraj C" first="C. A." last="Gunraj">C. A. Gunraj</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Neurology, Krembil Neuroscience Centre and Toronto Western Research Institute, University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Wagle Shukla, A" sort="Wagle Shukla, A" uniqKey="Wagle Shukla A" first="A." last="Wagle-Shukla">A. Wagle-Shukla</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Neurology, Krembil Neuroscience Centre and Toronto Western Research Institute, University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Moro, E" sort="Moro, E" uniqKey="Moro E" first="E." last="Moro">E. Moro</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Neurology, Krembil Neuroscience Centre and Toronto Western Research Institute, University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Lozano, A M" sort="Lozano, A M" uniqKey="Lozano A" first="A. M." last="Lozano">A. M. Lozano</name><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Division of Neurosurgery, Krembil Neuroscience Centre and Toronto Western Research Institute, University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>7 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Lang, A E" sort="Lang, A E" uniqKey="Lang A" first="A. E." last="Lang">A. E. Lang</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Neurology, Krembil Neuroscience Centre and Toronto Western Research Institute, University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Chen, R" sort="Chen, R" uniqKey="Chen R" first="R." last="Chen">R. Chen</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Neurology, Krembil Neuroscience Centre and Toronto Western Research Institute, University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author></analytic><series><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Nervous system diseases</term><term>Parkinson disease</term><term>Subthalamic nucleus</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term><term>Parkinson maladie</term><term>Noyau sousthalamique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Peripheral sensory stimulation at the wrist inhibits the motor cortex as measured by transcranial magnetic stimulation at interstimulus intervals of approximately 20 ms (short latency afferent inhibition [SAI]) and 200 ms (long latency afferent inhibition [LAI]). Previous studies suggested that reduced SAI in Parkinson disease (PD) reflects adverse effect of dopaminergic medications and reduced LAI may be related to nondopaminergic manifestations of PD. We hypothesize that subthalamic nucleus (STN) deep brain stimulation (DBS) may correct these deficiencies. Methods: We studied the effects of STN DBS on SAI and LAI in seven PD patients and age-matched controls. PD patients were studied in an off medication followed by an on medication session, with the stimulator switched on or off in random order in each session. Results: In the on medication session, SAI was reduced in the stimulator off condition and was restored by STN DBS. LAI was partially normalized by STN DBS in the medication on condition. Conclusions: Subthalamic nucleus (STN) stimulation improves short latency afferent inhibition, suggesting that it could normalize pathways that are adversely affected by dopaminergic medications. The effect of STN stimulation on long latency afferent inhibition suggests that it may influence nondopaminergic pathways involved in sensorimotor integration.</div></front></TEI><affiliations><list><country><li>Canada</li><li>Suède</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><region name="Ontario"><name sortKey="Sailer, A" sort="Sailer, A" uniqKey="Sailer A" first="A." last="Sailer">A. Sailer</name></region><name sortKey="Chen, R" sort="Chen, R" uniqKey="Chen R" first="R." last="Chen">R. Chen</name><name sortKey="Cunic, D I" sort="Cunic, D I" uniqKey="Cunic D" first="D. I." last="Cunic">D. I. Cunic</name><name sortKey="Gunraj, C A" sort="Gunraj, C A" uniqKey="Gunraj C" first="C. A." last="Gunraj">C. A. Gunraj</name><name sortKey="Lang, A E" sort="Lang, A E" uniqKey="Lang A" first="A. E." last="Lang">A. E. Lang</name><name sortKey="Lozano, A M" sort="Lozano, A M" uniqKey="Lozano A" first="A. M." last="Lozano">A. M. Lozano</name><name sortKey="Moro, E" sort="Moro, E" uniqKey="Moro E" first="E." last="Moro">E. Moro</name><name sortKey="Paradiso, G O" sort="Paradiso, G O" uniqKey="Paradiso G" first="G. O." last="Paradiso">G. O. Paradiso</name><name sortKey="Wagle Shukla, A" sort="Wagle Shukla, A" uniqKey="Wagle Shukla A" first="A." last="Wagle-Shukla">A. Wagle-Shukla</name></country><country name="Suède"><noRegion><name sortKey="Sailer, A" sort="Sailer, A" uniqKey="Sailer A" first="A." last="Sailer">A. Sailer</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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